Accueil > Séminaires > Séminaires à venir > Transforming proteins into functional biomaterials for complex tissue engineering

Transforming proteins into functional biomaterials for complex tissue engineering

Alvaro Mata School of Engineering & Materials Science Queen Mary, University of London

There is great interest to develop new materials with properties that
resemble those of biological systems such as hierarchical organization,
the capacity to grow or self-heal, and the ability to guide complex
biological processes. These kinds of materials would open opportunities to
engineer tissues with a much-needed higher level of complexity and
functionality. To this end, supramolecular chemistry offers an exciting
opportunity to grow such materials from the bottom-up using molecules and
processes found in nature. However, the ability to transform molecular and
nano-scale design into functional devices with practical utility at the
macroscale remains a challenge. The talk will describe new strategies that
integrate supramolecular chemistry with engineering principles to develop
practical materials with tuneable and advanced properties such as
hierarchical organization, the capacity to grow, tuneable mechanical
properties, and specific bioactivity [1-3]. These materials are being used
towards new regenerative therapies of tissues such as enamel, bone, and
blood vessels as well as more biologically relevant in vitro models for
applications such as cancer and neurological disorders.

References

Hedegaard et al (2018). Advanced Functional Materials 10.1002/adfm.201703716.
Elsharkawy et al (2018). Nature Communications 10.1038/s41467-018-04319-0.
Inostroza-Brito et al (2015). Nature Chemistry 7(11), 897-904. 10.1038/nchem.2349.

Dans la même rubrique :