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Transforming proteins into functional biomaterials for complex tissue engineering

Alvaro Mata School of Engineering & Materials Science Queen Mary, University of London

Jeudi 31 janvier 2019 - 14h00 - Amphi Urbain


There is great interest to develop new materials with properties that
resemble those of biological systems such as hierarchical organization,
the capacity to grow or self-heal, and the ability to guide complex
biological processes. These kinds of materials would open opportunities to
engineer tissues with a much-needed higher level of complexity and
functionality. To this end, supramolecular chemistry offers an exciting
opportunity to grow such materials from the bottom-up using molecules and
processes found in nature. However, the ability to transform molecular and
nano-scale design into functional devices with practical utility at the
macroscale remains a challenge. The talk will describe new strategies that
integrate supramolecular chemistry with engineering principles to develop
practical materials with tuneable and advanced properties such as
hierarchical organization, the capacity to grow, tuneable mechanical
properties, and specific bioactivity [1-3]. These materials are being used
towards new regenerative therapies of tissues such as enamel, bone, and
blood vessels as well as more biologically relevant in vitro models for
applications such as cancer and neurological disorders.


Hedegaard et al (2018). Advanced Functional Materials 10.1002/adfm.201703716.
Elsharkawy et al (2018). Nature Communications 10.1038/s41467-018-04319-0.
Inostroza-Brito et al (2015). Nature Chemistry 7(11), 897-904. 10.1038/nchem.2349.

Dynamics of Active Particles

Cécile Cottin-Bizonne Institut Lumière Matière, Université C. Bernard, Lyon

Jeudi 14 février 2019 - 14h00- Amphi Holweck


The behavior of self-propelled particles, that are intrinsically out of equilibrium, is rather fascinating and opens new questions. Here we study experimentally the dynamics of active colloids : from the behavior at low density up to crowded conditions. Our system is a monolayer of micron-size gold-platinum Janus particles in water. Upon addition of hydrogen peroxide, the colloids become self-propelled due to the different chemical gradient on both sides. If at low density they behave as perfect hot gas, at intermediate densities we observe a new phenomena : the formation of clusters. Measuring the aggregation and fragmentation rates we have rationalized the cluster size distribution and fluctuations. In the dense regime, we notice an unexpected non-monotonic behavior as the activity level rises up.

In a second part I will present experimental studies on the dynamics of interfacial swimmers : the spontaneous motion of camphor particles at a liquid-gas interface. Those Marangoni swimmers present complex problems starting with the simplest question of their swimming properties when symmetry breaking arises spontaneously rather than being encoded in the particle properties. I will discuss recent investigations we conducted on the dynamics of lonely camphor swimmer as well as on the original collective dynamics emerging from the interactions between many swimmers.

Contrôle et manipulation d’ondes hydro-élastiques

Antonin Eddi Laboratoire PMMH, ESPCI

Jeudi 10 janvier 2019

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DNA materials micro-structuration and strain sensing

Rémi Merindol Centre de Recherche Paul Pascal, Bordeaux, France

Jeudi 6 décembre 2018

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Mechanical properties of poorly connected soft solids

Mehdi Bouzid LPTMS, CNRS, Univ. Paris-Sud, Univ. Paris-Saclay

Jeudi 29 novembre 2018

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